Two sample MR report

Telomere_length against aparc-Desikan lh volume frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0395656	0.1052548	0.7107594
Weighted median	23	0.0225690	0.0554353	0.6839171
Inverse variance weighted	23	-0.0186766	0.0402294	0.6424659
Simple mode	23	0.0147862	0.0970527	0.8802975
Weighted mode	23	0.0061803	0.0623275	0.9219101

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.54312	21	0.3157179
Inverse variance weighted	23.59523	22	0.3687984

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012826	0.0059488	0.8313763

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000722	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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