Two sample MR report

Telomere_length against aparc-Desikan lh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0108392	0.1340799	0.9363334
Weighted median	23	-0.0418292	0.0553040	0.4494388
Inverse variance weighted	23	-0.0569759	0.0513605	0.2672868
Simple mode	23	-0.0941501	0.0994902	0.3542617
Weighted mode	23	-0.0564726	0.0598840	0.3559057

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.20429	21	0.0121962
Inverse variance weighted	38.45852	22	0.0162658

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028328	0.0075779	0.712284

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8