Two sample MR report

Telomere_length against aparc-Desikan lh volume cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1212342	0.1518886	0.4337013
Weighted median	23	-0.0585947	0.0621898	0.3460945
Inverse variance weighted	23	-0.0285418	0.0585938	0.6261779
Simple mode	23	-0.1820597	0.1143937	0.1257611
Weighted mode	23	-0.1582285	0.0763804	0.0502321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.03045	21	0.0004969
Inverse variance weighted	50.05670	22	0.0005762

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056913	0.0085843	0.514554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001533	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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