Two sample MR report

Telomere_length against aparc-Desikan lh volume caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1311456	0.1050971	0.2258212
Weighted median	23	-0.0774126	0.0563076	0.1691886
Inverse variance weighted	23	-0.1108670	0.0401667	0.0057771
Simple mode	23	-0.0718936	0.0994671	0.4774243
Weighted mode	23	-0.0906762	0.0645754	0.1742221

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.47350	21	0.3192613
Inverse variance weighted	23.52261	22	0.3727407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012451	0.0059398	0.8359861

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009596	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8