Two sample MR report

Telomere_length against aparc-Desikan lh volume caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0095475	0.0994066	0.9243951
Weighted median	23	-0.0367712	0.0560261	0.5116170
Inverse variance weighted	23	-0.0263474	0.0388456	0.4976068
Simple mode	23	-0.0592175	0.1064816	0.5837353
Weighted mode	23	-0.0592175	0.0846026	0.4912950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.11386	21	0.5778359
Inverse variance weighted	19.14757	22	0.6361988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010315	0.0056183	0.8560881

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005942	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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