Two sample MR report

Telomere_length against aparc-Desikan lh volume bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0216691	0.1204894	0.8590006
Weighted median	23	-0.0187672	0.0592312	0.7513598
Inverse variance weighted	23	-0.0521414	0.0464842	0.2619895
Simple mode	23	0.1019220	0.1120326	0.3728129
Weighted mode	23	-0.0468877	0.0709776	0.5157280

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.85274	21	0.0761439
Inverse variance weighted	31.50344	22	0.0862648

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045319	0.0068098	0.5129709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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