Two sample MR report

Telomere_length against aparc-Desikan lh thickness transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1195114	0.1190430	0.3268387
Weighted median	23	-0.0337846	0.0555151	0.5428121
Inverse variance weighted	23	-0.0370310	0.0460585	0.4213983
Simple mode	23	-0.0265930	0.0787673	0.7388538
Weighted mode	23	-0.0301622	0.0591951	0.6154478

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.11632	21	0.0896754
Inverse variance weighted	30.92886	22	0.0975805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050642	0.0067279	0.4599773

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009647	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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