Two sample MR report

Telomere_length against aparc-Desikan lh thickness supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2314999	0.0994051	0.0299332
Weighted median	23	-0.1066325	0.0556576	0.0553821
Inverse variance weighted	23	-0.0762605	0.0388452	0.0496241
Simple mode	23	-0.2549338	0.1001209	0.0184037
Weighted mode	23	-0.1116352	0.0660693	0.1052149

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.48358	21	0.6814087
Inverse variance weighted	20.36199	22	0.5604078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095317	0.0056182	0.1045493

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007338	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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