Two sample MR report

Telomere_length against aparc-Desikan lh thickness superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1748648	0.1112442	0.1309195
Weighted median	23	-0.0584794	0.0590990	0.3224105
Inverse variance weighted	23	-0.0591627	0.0437441	0.1762246
Simple mode	23	0.0029536	0.1026332	0.9773012
Weighted mode	23	-0.0038705	0.0792532	0.9614900

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.30038	21	0.1952264
Inverse variance weighted	27.89934	22	0.1790413

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071041	0.0062873	0.2712518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009156	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8