Two sample MR report

Telomere_length against aparc-Desikan lh thickness superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2515843	0.1153246	0.0406534
Weighted median	23	-0.0499682	0.0594589	0.4006937
Inverse variance weighted	23	-0.0868978	0.0464853	0.0615728
Simple mode	23	-0.0130152	0.1131055	0.9094321
Weighted mode	23	-0.0297593	0.0928491	0.7516041

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.26692	21	0.1327422
Inverse variance weighted	31.50658	22	0.0862060

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101119	0.006518	0.1357499

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011062	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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