Two sample MR report

Telomere_length against aparc-Desikan lh thickness superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2023556	0.1249820	0.1203520
Weighted median	23	0.0032290	0.0616554	0.9582327
Inverse variance weighted	23	-0.0486212	0.0497051	0.3279791
Simple mode	23	0.0046902	0.1070449	0.9654471
Weighted mode	23	0.0163629	0.0953290	0.8652848

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.19883	21	0.0440584
Inverse variance weighted	36.02188	22	0.0302027

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094394	0.0070638	0.1957476

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011389	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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