Two sample MR report

Telomere_length against aparc-Desikan lh thickness rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0975815	0.0994058	0.3374481
Weighted median	23	0.0042217	0.0561755	0.9400942
Inverse variance weighted	23	-0.0161986	0.0388454	0.6766758
Simple mode	23	0.0561662	0.0996336	0.5786410
Weighted mode	23	-0.0033926	0.0697020	0.9616187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.38432	21	0.6245702
Inverse variance weighted	19.17538	22	0.6344749

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049969	0.0056182	0.383856

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005863	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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