Two sample MR report

Telomere_length against aparc-Desikan lh thickness rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0204436	0.1063706	0.8494382
Weighted median	23	0.0575975	0.0575508	0.3169186
Inverse variance weighted	23	0.0219255	0.0407918	0.5909247
Simple mode	23	0.1267410	0.0981310	0.2099185
Weighted mode	23	0.0615783	0.0652128	0.3552888

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.04516	21	0.2908754
Inverse variance weighted	24.25956	22	0.3337721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026014	0.0060118	0.6696279

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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