Two sample MR report

Telomere_length against aparc-Desikan lh thickness precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3447907	0.1172048	0.0077900
Weighted median	23	-0.0570793	0.0611277	0.3504214
Inverse variance weighted	23	-0.0671413	0.0513222	0.1907945
Simple mode	23	-0.0656057	0.1068855	0.5456462
Weighted mode	23	-0.0858138	0.0815793	0.3042601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.19617	21	0.1093709
Inverse variance weighted	38.40443	22	0.0164968

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.017048	0.0066243	0.0177105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012542	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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