Two sample MR report

Telomere_length against aparc-Desikan lh thickness precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1889071	0.0994051	0.0712003
Weighted median	23	-0.1425061	0.0568239	0.0121466
Inverse variance weighted	23	-0.0966387	0.0388451	0.0128538
Simple mode	23	-0.1350919	0.0943014	0.1660422
Weighted mode	23	-0.1428388	0.0658380	0.0411182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.26251	21	0.6323365
Inverse variance weighted	19.27936	22	0.6280203

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056653	0.0056181	0.3247468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007718	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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