Two sample MR report

Telomere_length against aparc-Desikan lh thickness posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1225465	0.1046049	0.2545115
Weighted median	23	-0.0515878	0.0592170	0.3836643
Inverse variance weighted	23	0.0279588	0.0421966	0.5075972
Simple mode	23	0.1754150	0.1117872	0.1308764
Weighted mode	23	-0.0636702	0.0733811	0.3949435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.25341	21	0.3306176
Inverse variance weighted	25.95881	22	0.2534545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.009241	0.005912	0.1329774

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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