Two sample MR report

Telomere_length against aparc-Desikan lh thickness postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2586938	0.0994046	0.0166271
Weighted median	23	-0.1398262	0.0557541	0.0121448
Inverse variance weighted	23	-0.1098354	0.0388449	0.0046907
Simple mode	23	-0.1884057	0.0835753	0.0344696
Weighted mode	23	-0.1457750	0.0611731	0.0262369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.07045	21	0.6445414
Inverse variance weighted	20.71712	22	0.5382743

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091399	0.0056181	0.1186799

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00087	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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