Two sample MR report

Telomere_length against aparc-Desikan lh thickness pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3230164	0.1074076	0.0067076
Weighted median	23	-0.1070867	0.0576849	0.0633956
Inverse variance weighted	23	-0.0961472	0.0458611	0.0360391
Simple mode	23	-0.1779136	0.0969954	0.0801791
Weighted mode	23	-0.1144887	0.0604722	0.0715536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.51758	21	0.2686618
Inverse variance weighted	30.66518	22	0.1031731

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0139297	0.0060704	0.0321579

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8