Two sample MR report

Telomere_length against aparc-Desikan lh thickness parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0883903	0.1050088	0.4094161
Weighted median	23	-0.0743343	0.0576499	0.1972559
Inverse variance weighted	23	-0.0041228	0.0408102	0.9195324
Simple mode	23	-0.0815374	0.1057742	0.4489882
Weighted mode	23	-0.0868285	0.0710782	0.2347911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.43404	21	0.3212800
Inverse variance weighted	24.28217	22	0.3326144

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005174	0.0059349	0.3931756

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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