Two sample MR report

Telomere_length against aparc-Desikan lh thickness parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1974959	0.0999135	0.0613587
Weighted median	23	-0.0788167	0.0636005	0.2152541
Inverse variance weighted	23	-0.0586817	0.0401622	0.1439829
Simple mode	23	0.1115914	0.1229125	0.3737734
Weighted mode	23	0.0771328	0.0884785	0.3927493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.21502	21	0.4458818
Inverse variance weighted	23.51651	22	0.3730727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085233	0.005647	0.1461066

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007818	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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