Two sample MR report

Telomere_length against aparc-Desikan lh thickness parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1692039	0.0994049	0.1034828
Weighted median	23	0.0061436	0.0600184	0.9184690
Inverse variance weighted	23	-0.0210995	0.0388452	0.5870132
Simple mode	23	0.0535473	0.1114725	0.6357111
Weighted mode	23	0.0199700	0.0822067	0.8103145

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58446	21	0.6117777
Inverse variance weighted	21.20437	22	0.5081404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090936	0.0056182	0.1204526

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006515	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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