Two sample MR report

Telomere_length against aparc-Desikan lh thickness parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1520521	0.0994069	0.1410423
Weighted median	23	-0.0630321	0.0541032	0.2440049
Inverse variance weighted	23	-0.0764331	0.0388454	0.0491116
Simple mode	23	-0.0563697	0.0867723	0.5226582
Weighted mode	23	-0.0612799	0.0639655	0.3484660

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.48515	21	0.7418032
Inverse variance weighted	17.16811	22	0.7540159

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004643	0.0056183	0.4178619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006375	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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