Two sample MR report

Telomere_length against aparc-Desikan lh thickness paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2534292	0.1287286	0.0623258
Weighted median	23	-0.0067685	0.0633863	0.9149626
Inverse variance weighted	23	-0.0423943	0.0527290	0.4213947
Simple mode	23	0.0252002	0.1150987	0.8287121
Weighted mode	23	0.0024754	0.0927959	0.9789590

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.21838	21	0.0267155
Inverse variance weighted	40.53793	22	0.0093484

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0129575	0.0072754	0.0893848

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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