Two sample MR report

Telomere_length against aparc-Desikan lh thickness middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0908595	0.1148563	0.4377463
Weighted median	23	0.0522189	0.0554679	0.3464862
Inverse variance weighted	23	0.0216407	0.0450176	0.6307176
Simple mode	23	0.0503778	0.0856247	0.5622852
Weighted mode	23	0.0365736	0.0618637	0.5604143

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.03516	21	0.1391570
Inverse variance weighted	29.54679	22	0.1299021

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069074	0.0064914	0.2993681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009046	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8