Two sample MR report

Telomere_length against aparc-Desikan lh thickness medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1332995	0.1012239	0.2020702
Weighted median	23	0.0203243	0.0557589	0.7154815
Inverse variance weighted	23	-0.0168166	0.0400587	0.6746326
Simple mode	23	0.0339048	0.0985367	0.7340508
Weighted mode	23	-0.0080368	0.0685398	0.9077198

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.77524	21	0.4125597
Inverse variance weighted	23.39581	22	0.3796760

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007152	0.0057209	0.2249971

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007146	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8