Two sample MR report

Telomere_length against aparc-Desikan lh thickness lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2229665	0.1172642	0.0710593
Weighted median	23	-0.0626308	0.0577093	0.2777967
Inverse variance weighted	23	-0.0408422	0.0477083	0.3919525
Simple mode	23	-0.0331317	0.0986276	0.7401089
Weighted mode	23	-0.0604904	0.0615921	0.3367222

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.22317	21	0.1087458
Inverse variance weighted	33.18483	22	0.0593208

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0111824	0.0066275	0.1063507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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