Two sample MR report

Telomere_length against aparc-Desikan lh thickness lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0657870	0.1096351	0.5548909
Weighted median	23	-0.0548638	0.0617613	0.3743689
Inverse variance weighted	23	-0.0452263	0.0418990	0.2804037
Simple mode	23	-0.1747201	0.1312630	0.1967969
Weighted mode	23	-0.0983136	0.0712790	0.1816699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.54364	21	0.2243867
Inverse variance weighted	25.59413	22	0.2695152

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012624	0.0061964	0.8405206

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008166	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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