Two sample MR report

Telomere_length against aparc-Desikan lh thickness lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3002000	0.1047691	0.0092627
Weighted median	23	-0.1862720	0.0590806	0.0016169
Inverse variance weighted	23	-0.1308606	0.0428361	0.0022513
Simple mode	23	-0.1666422	0.1105091	0.1457946
Weighted mode	23	-0.2130102	0.0790983	0.0132862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.32889	21	0.3266965
Inverse variance weighted	26.75413	22	0.2207141

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0103976	0.0059214	0.093676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011545	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8