Two sample MR report

Telomere_length against aparc-Desikan lh thickness isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1064561	0.0994073	0.2963650
Weighted median	23	0.0879379	0.0566124	0.1203439
Inverse variance weighted	23	0.0503264	0.0388458	0.1951327
Simple mode	23	0.0733463	0.0891173	0.4193225
Weighted mode	23	0.0882286	0.0657158	0.1930988

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.51379	21	0.6795305
Inverse variance weighted	17.89007	22	0.7124856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034464	0.0056183	0.5461874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8