Two sample MR report

Telomere_length against aparc-Desikan lh thickness inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1515964	0.1373591	0.2822315
Weighted median	23	-0.0323088	0.0603983	0.5926993
Inverse variance weighted	23	-0.0709245	0.0529482	0.1804058
Simple mode	23	-0.0907209	0.1005525	0.3767101
Weighted mode	23	-0.0244124	0.0793347	0.7611942

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.09816	21	0.0072350
Inverse variance weighted	40.87548	22	0.0085268

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049532	0.0077632	0.5303446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013395	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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