Two sample MR report

Telomere_length against aparc-Desikan lh thickness inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1615644	0.1131714	0.1681074
Weighted median	23	-0.0317107	0.0573436	0.5802665
Inverse variance weighted	23	-0.0609299	0.0441576	0.1676392
Simple mode	23	0.0669535	0.1040559	0.5265912
Weighted mode	23	-0.0962042	0.0699651	0.1829648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.21952	21	0.1637047
Inverse variance weighted	28.42913	22	0.1618918

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006179	0.0063962	0.3450207

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000936	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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