Two sample MR report

Telomere_length against aparc-Desikan lh thickness fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0756709	0.1256748	0.5535425
Weighted median	23	-0.0861403	0.0625521	0.1684824
Inverse variance weighted	23	-0.0375777	0.0481051	0.4347095
Simple mode	23	-0.1243315	0.1001124	0.2273436
Weighted mode	23	-0.1098065	0.0760013	0.1626080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.56595	21	0.0403063
Inverse variance weighted	33.73927	22	0.0522042

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023389	0.0071028	0.745196

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010507	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8