Two sample MR report

Telomere_length against aparc-Desikan lh thickness frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0421188	0.1185231	0.7258619
Weighted median	23	-0.0467157	0.0628866	0.4575684
Inverse variance weighted	23	-0.0016566	0.0453991	0.9708912
Simple mode	23	0.0027568	0.1136787	0.9808710
Weighted mode	23	-0.0593006	0.0810380	0.4720370

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.85383	21	0.0949648
Inverse variance weighted	30.04937	22	0.1172693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024844	0.0066987	0.7144449

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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