Two sample MR report

Telomere_length against aparc-Desikan lh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0204554	0.1150126	0.8605423
Weighted median	23	0.0027156	0.0558687	0.9612331
Inverse variance weighted	23	-0.0250111	0.0439125	0.5689725
Simple mode	23	0.0742568	0.0867228	0.4010874
Weighted mode	23	0.0213930	0.0599521	0.7246153

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.11069	21	0.1370397
Inverse variance weighted	28.11317	22	0.1719608

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002797	0.0065002	0.966083

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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