Two sample MR report

Telomere_length against aparc-Desikan lh thickness cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2304130	0.1122279	0.0527314
Weighted median	23	-0.0695593	0.0559711	0.2139522
Inverse variance weighted	23	-0.0601435	0.0455348	0.1865593
Simple mode	23	-0.0229936	0.0919890	0.8049377
Weighted mode	23	-0.0677121	0.0611030	0.2797594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.76705	21	0.1786976
Inverse variance weighted	30.22978	22	0.1129857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104545	0.0063428	0.1141865

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009886	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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