Two sample MR report

Telomere_length against aparc-Desikan lh thickness caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1404970	0.0994063	0.1722017
Weighted median	23	-0.0622156	0.0525791	0.2366997
Inverse variance weighted	23	-0.0273246	0.0388455	0.4817960
Simple mode	23	-0.0834759	0.0791813	0.3032152
Weighted mode	23	-0.0625992	0.0584520	0.2958005

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.37209	21	0.6883191
Inverse variance weighted	18.90183	22	0.6513823

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069487	0.0056182	0.2298045

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005877	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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