Two sample MR report

Telomere_length against aparc-Desikan lh thickness caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1764789	0.0994069	0.0903416
Weighted median	23	-0.0439363	0.0570549	0.4412574
Inverse variance weighted	23	-0.0298048	0.0388458	0.4429266
Simple mode	23	0.0391102	0.0993735	0.6976883
Weighted mode	23	-0.0524061	0.0647941	0.4272854

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.47985	21	0.6816403
Inverse variance weighted	20.04930	22	0.5799558

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090058	0.0056182	0.1238816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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