Two sample MR report

Telomere_length against aparc-Desikan lh thickness bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0698139	0.1011286	0.4975354
Weighted median	23	-0.0367307	0.0556731	0.5094097
Inverse variance weighted	23	-0.0131935	0.0389487	0.7348060
Simple mode	23	-0.0870944	0.0959720	0.3739772
Weighted mode	23	-0.0354515	0.0620488	0.5735541

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.7341	21	0.4149688
Inverse variance weighted	22.1170	22	0.4529237

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034765	0.0057155	0.5495445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006737	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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