Two sample MR report

Telomere_length against aparc-Desikan lh thickness GlobalMeanThickness

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2538790	0.1125600	0.0348963
Weighted median	23	-0.0561148	0.0599277	0.3490801
Inverse variance weighted	23	-0.0827826	0.0456798	0.0699498
Simple mode	23	-0.0531937	0.1046906	0.6164373
Weighted mode	23	-0.0637775	0.0798592	0.4330455

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.92702	21	0.1732818
Inverse variance weighted	30.42365	22	0.1085258

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105054	0.0063617	0.1135427

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010594	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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