Two sample MR report

Telomere_length against aparc-Desikan lh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2324208	0.1022369	0.0336231
Weighted median	23	-0.1288382	0.0574578	0.0249413
Inverse variance weighted	23	-0.0903472	0.0410970	0.0279213
Simple mode	23	-0.1619314	0.1030830	0.1304820
Weighted mode	23	-0.1487223	0.0624654	0.0263564

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.21402	21	0.3872679
Inverse variance weighted	24.62496	22	0.3153437

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087234	0.0057782	0.146022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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