Two sample MR report

Telomere_length against aparc-Desikan lh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0141632	0.0994059	0.8880602
Weighted median	23	-0.0676089	0.0546629	0.2161489
Inverse variance weighted	23	-0.0720237	0.0388453	0.0637224
Simple mode	23	-0.0811463	0.0900542	0.3773031
Weighted mode	23	-0.0670193	0.0621831	0.2928109

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.69343	21	0.6683136
Inverse variance weighted	18.58063	22	0.6710614

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052918	0.0056182	0.3569464

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8