Two sample MR report

Telomere_length against aparc-Desikan lh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0136913	0.1068211	0.8992337
Weighted median	23	-0.0735566	0.0594946	0.2163259
Inverse variance weighted	23	-0.0518549	0.0412125	0.2083079
Simple mode	23	-0.1433803	0.1025677	0.1760770
Weighted mode	23	-0.1433803	0.0863110	0.1108584

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.24997	21	0.2811051
Inverse variance weighted	24.76311	22	0.3085367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040245	0.0060373	0.5122785

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008044	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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