Two sample MR report

Telomere_length against aparc-Desikan lh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0197996	0.0994168	0.8440555
Weighted median	23	0.0003310	0.0650170	0.9959380
Inverse variance weighted	23	0.0004341	0.0388451	0.9910841
Simple mode	23	-0.0102940	0.1123233	0.9278086
Weighted mode	23	-0.0156081	0.1029335	0.8808581

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.00476	21	0.4586533
Inverse variance weighted	21.04956	22	0.5176773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001189	0.0056189	0.8344459

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006378	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8