Two sample MR report

Telomere_length against aparc-Desikan lh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0224549	0.1232294	0.8571577
Weighted median	23	-0.0216935	0.0591803	0.7139425
Inverse variance weighted	23	-0.0699147	0.0472433	0.1389040
Simple mode	23	-0.1296632	0.1096409	0.2495849
Weighted mode	23	-0.0513691	0.0701611	0.4718005

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.27215	21	0.0549372
Inverse variance weighted	32.54118	22	0.0686263

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002914	0.0069647	0.6799009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010842	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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