Two sample MR report

Telomere_length against aparc-Desikan lh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0224198	0.1220702	0.8560398
Weighted median	23	-0.1429773	0.0631080	0.0234760
Inverse variance weighted	23	-0.0778339	0.0468745	0.0968191
Simple mode	23	-0.1507028	0.1078403	0.1762094
Weighted mode	23	-0.1648876	0.0726840	0.0334547

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.66871	21	0.0632264
Inverse variance weighted	32.03548	22	0.0767931

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034024	0.0068991	0.6270122

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010924	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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