Two sample MR report

Telomere_length against aparc-Desikan lh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0061312	0.1174439	0.9588583
Weighted median	23	-0.1330338	0.0591554	0.0245198
Inverse variance weighted	23	-0.0748476	0.0454341	0.0994781
Simple mode	23	-0.1542435	0.1143525	0.1911089
Weighted mode	23	-0.1575604	0.0805366	0.0632331

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.31318	21	0.1066834
Inverse variance weighted	30.09641	22	0.1161399

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049721	0.0066377	0.4621227

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8