Two sample MR report

Telomere_length against aparc-Desikan lh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0829221	0.1346534	0.5446314
Weighted median	23	0.0079306	0.0637273	0.9009624
Inverse variance weighted	23	0.0020926	0.0519816	0.9678883
Simple mode	23	-0.1186564	0.1211226	0.3379153
Weighted mode	23	0.0130395	0.0829980	0.8765944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.53332	21	0.0111531
Inverse variance weighted	39.39657	22	0.0127051

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052199	0.0076103	0.500281

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011938	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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