Two sample MR report

Telomere_length against aparc-Desikan lh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1275290	0.0994060	0.2135025
Weighted median	23	-0.0859059	0.0555337	0.1218836
Inverse variance weighted	23	-0.0468449	0.0388454	0.2278443
Simple mode	23	-0.1258549	0.0928192	0.1888821
Weighted mode	23	-0.0949688	0.0576916	0.1139463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.87478	21	0.829182
Inverse variance weighted	15.65231	22	0.832759

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004954	0.0056182	0.3878795

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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