Two sample MR report

Telomere_length against aparc-Desikan lh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0280104	0.1210352	0.8192259
Weighted median	23	-0.0501002	0.0591476	0.3969742
Inverse variance weighted	23	-0.0579495	0.0462898	0.2106116
Simple mode	23	-0.0266753	0.0946845	0.7807853
Weighted mode	23	-0.0454913	0.0719293	0.5336152

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.13257	21	0.0714798
Inverse variance weighted	31.23962	22	0.0913154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018383	0.0068406	0.7907627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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