Two sample MR report

Telomere_length against aparc-Desikan lh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0867791	0.1024457	0.4065044
Weighted median	23	-0.0247305	0.0553881	0.6552395
Inverse variance weighted	23	-0.0030968	0.0398394	0.9380406
Simple mode	23	-0.0113852	0.0955966	0.9062800
Weighted mode	23	-0.0391773	0.0638486	0.5457739

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.30400	21	0.3821770
Inverse variance weighted	23.14039	22	0.3938391

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051381	0.00579	0.3849112

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8